3,3,3',3'-四甲基-1,1'-螺BI(茚滿)-6,6'-二醇 |
| CAS No.: |
1568-80-5 |
| 分子式： |
C21H24O2 |
| 分子量： |
308.45 |
| 備注： |
中文名稱3,3,3’,3’-四甲基-1,1’-螺BI(茚滿)-6,6’-二醇中文同義詞螺二茚滿;3,3,3’,3’-四甲基螺環(huán)二酚;3,3,3’,3’-四甲基-2,2’,3,3’-四氫-1,1’-螺二[茚滿]-6,6’-二醇;螺雙茚滿;3,3,3’,3’-四甲基-1,1’-螺BI(茚滿)-6,6’-二醇;3,3,3’,3’-四甲基-2,2’,3,3’-四氫-1,1’-螺聯(lián)[茚]-6,6’-二醇;HIV-1整合酶抑制劑8;3,3,3,3-四甲基-2,2,3,3-四氫-1,1-螺雙[茚]-6,6-二醇英文名稱SPIROBIINDANE英文同義詞SPIROBIINDANE;2,2’’,3,3’’-TETRAHYDRO-3,3,3’’,3’’-TETRAMETHYL-1,1’’-SPIROBI-1H-INDENE-6,6’’-DIOL;tetrahydrotetramethyl-1,1’-spirobi-1H-indene-6,6’-diol;3,3,3’,3’-Tetramethyl-1,1’-spirobi[indan]-6,6’-diol;3,3,3’,3’-Tetramethyl-2,2’,3,3’-tetrahydro[1,1’-spirobi[1H-indene]]-6,6’-diol;3,3,3’,3’-Tetramethyl-2,2’,3,3’-tetrahydro-1,1’-spirobi[1H-indene]-6,6’-diol;6,6’-Dihydroxy-3,3,3’,3’-tetramethyl-1,1’-spirobiindan;6,6’-Dihydroxy-3,3,3’,3’-tetramethyl-1,1’-spirobiindaneCAS號(hào)1568-80-5分子式C21H24O2分子量308.41EINECS號(hào)相關(guān)類別醇;化學(xué)試劑Mol文件1568-80-5.mol結(jié)構(gòu)式3,3,3’,3’-四甲基-1,1’-螺BI(茚滿)-6,6’-二醇性質(zhì)熔點(diǎn)213-214°C沸點(diǎn)478.5±45.0°C(Predicted)密度1.21±0.1g/cm3(Predicted)儲(chǔ)存條件Storeat-20°C溶解度DMSO：125mg/mL（405.30mM；需要超聲波）Chemicalbook酸度系數(shù)(pKa)9.98±0.60(Predicted)形態(tài)固體顏色白色至米白色CAS數(shù)據(jù)庫(kù)1568-80-5EPA化學(xué)物質(zhì)信息1,1’-Spirobi[1H-indene]-6,6’-diol,2,2’,3,3’-tetrahydro-3,3,3’,3’-tetramethyl-(1568-80-5)3,3,3’,3’-四甲基-1,1’-螺BI(茚滿)-6,6’-二醇用途與合成方法生物活性HIV-1integraseinhibitor8是HIV-1整合酶(HIV-1integrase)抑制劑，化合物8。體外研究HIV-1integraseinhibitor8isagainst3′-processing(TC)andstrand-transfer(ST)activitiesinthepresenceofMn2+asthecationiccofactorbygelassaywithIC50valuesof275μMand200μM,respectively.Itinhibitsthestrand-transfer(ST)activitywithanIC50valueof200μM.TheDNArelaxationactivityofMCVtopoisomeraseismonitoredbygelelectrophoresis,whileDNAcleavageandreligationactivitiesweremonitoredusingamicrotiterassay.HIV-1integraseinhibitor8inhibitsMCVtopoisomeraseandDNAreligationwithIC50valuesof500μMand200μM,respectively.Thisresultdemonstratesthatcompound8isinactiveagainsttopoisomeraseinbothassays.HIV-1integraseinhibitor8inducescellcytotoxicityandyieldsaLD50(doseatwhichthesignalisreduced50%duetocelldeath)of20μMinHeLacells. |
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