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2'-脫氧肌苷 |
| CAS No.: |
890-38-0 |
| 分子式： |
C10H12N4O4 |
| 分子量： |
252.23 |
| 備注： |
中文名稱2’-脫氧肌苷中文同義詞2ˊ-脫氧次黃嘌呤核苷;2ˊ-脫氧肌苷;9-(2-脫氧-Β-D-呋喃核糖基)次黃嘌呤;9-(2-脫氧-Β-D-呋喃核糖)黃嘌呤;2’-脫氧-肌苷水合物;2’-脫氧-肌苷一水合物;9-(2-脫氧-Β-D-呋喃核糖基)次黃嘌呤2’-脫氧次黃嘌呤核苷2’-脫氧肌苷;2’-脫氧肌苷,98+%英文名稱2’-Deoxyinosine英文同義詞DidanosineEPImpurityC;DidanosineImpurityⅢ:2’-Deoxyinosine;DidanosineImpurity3（DidanosineEPImpurityC）;2’-Deoxyinosine(Di);DEOXYINOSINE,2’-(RG);9-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-9H-purin-6-ol;9-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;1,9-Dihydro-9-(2’-deoxy-β-D-ribofuranosyl)-6H-purin-6-oneCAS號(hào)890-38-0分子式C10H12N4O4分子量252.23EINECS號(hào)212-964-1相關(guān)類別醫(yī)用原料;核苷;對(duì)照品;生化試劑-植物激素及核酸類;生化試劑;核酸;小分子抑制劑;其他生化試劑;化學(xué)試劑;植物激素及核酸類;核苷，核苷酸，寡核苷酸;醫(yī)用原料;PharmaceuticalRawMaterials;Pyridines,Pyrimidines,PurinesandPteredines;Biochemistry;Nucleosidesandtheiranalogs;Nucleosides,Nucleotides&RelatedReagents;Bases&RelatedReagents;Heterocycles;Impurities;Inhibitors;Intermediates&FineChemicals;Nucleotides;Pharmaceuticals;Heterocycles,Impurities,Inhibitors,Nucleotides,Bases&RelatedReagents,Pharmaceuticals,Intermediates&FineChemicals;有機(jī)溶劑;對(duì)照品;中藥對(duì)照品;醫(yī)藥原料;通用生化試劑-核酸;2’-脫氧類;有機(jī)化工原料Mol文件890-38-0.mol結(jié)構(gòu)式2’-脫氧肌苷性質(zhì)熔點(diǎn)250°C比旋光度21o(c=1,H2O22oC)沸點(diǎn)395.4°C(roughestimate)密度1.3402(rouChemicalbookghestimate)折射率-16°(C=1,H2O)儲(chǔ)存條件-20°C溶解度DMSO（少許）、水（少許）酸度系數(shù)(pKa)8.92±0.70(Predicted)形態(tài)粉末顏色白色至類白色水溶解性8.33g/L(25.02oC)BRN33517InChIInChI=1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1InChIKeyVGONTNSXDCQUGY-RRKCRQDMSA-NSMILESOC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)O)N=C2)C[C@@H]1OCAS數(shù)據(jù)庫890-38-0(CASDataBaseReference)NIST化學(xué)物質(zhì)信息Inosine,2’-deoxy-(890-38-0)2’-脫氧肌苷用途與合成方法生物活性2’-deoxyadenosine能夠抑制人癌細(xì)胞株的生長，并發(fā)現(xiàn)其與嘌呤核苷磷酸化酶(PNP)缺乏有關(guān)。靶點(diǎn)HumanEndogenousMetabolite體外研究Intheabsenceofdeoxycoformycin,2’-deoxyadenosineisprimarilydeaminatedto2’-deoxyinosineandthenconvertedintohypoxanthine.Inthepresenceoftheinhibitor,thedeoxynucleoside,inadditiontoaphosphorylationprocess,undergoesphosphorolyticcleavagegivingrisetoadenine.Theconversionof2’-deoxyadenosinetoadeninemightrepresentaprotectivedevice,emergingwhentheactivityofadenosinedeaminaseisreducedorinhibited.ThereismuchevidencetoindicatethattheenzymecatalyzingthisprocesssmaybedistinctfrommethylthioadenosinephosphorylaseandS-adenosylhomocysteinehydrolase,whicharetheenzymesreportedtoberesponsiblefortheformationofadeninefrom28-deoxyadenosineinmammals.化學(xué)性質(zhì)白色粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑。 |
| 結(jié)構(gòu)式： |
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金經(jīng)理 |
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