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L-硒代蛋氨酸 |
| CAS No.: |
3211-76-5 |
| 分子式： |
C5H11NO2Se |
| 分子量： |
196.11 |
| 備注： |
中文名稱L-硒代蛋氨酸中文同義詞L(+)硒代蛋氨酸;L-硒代蛋氨;硒代蛋氨酸;L-(+)-硒代蛋氨酸;硒基-L-甲硫氨酸;(S)-(+)-2-氨基-4-(甲基硒)丁酸;-硒代蛋氨酸;L-SELENOMETHIONINEL-硒代蛋氨酸英文名稱L-Selenomethionine英文同義詞(S)-(+)-2-AMINO-4-(METHYLSELENO)BUTANOICACID;(S)-2-AMINO-4-(METHYLSELENO)BUTYRICACID;SEMET;SELENOMETHIONINE,L-(+)-;SELENO-L-METHIONINE;L-(+)-2-AMINO-4-(METHYLSELENO)BUTANOICACID;L-(+)-SELENOMETHIONINE;L-SELENOMETHIONINECAS號(hào)3211-76-5分子式C5H11NO2Se分子量196.11EINECS號(hào)608-705-0相關(guān)類別醫(yī)藥原料藥;化學(xué)試劑;氨基酸類;細(xì)胞信號(hào)和神經(jīng)生物學(xué);食品添加劑;氨基酸;功能性物質(zhì)-硒代蛋氨酸;對(duì)照品;生化試劑-氨基酸類;新材料;化工原料;化工;AminoAcidDerivatives;Methionine[Met,M];AminoAcids;Antioxidant;Biochemistry;Biological-modifiedAminoAcids;ClassesofMetalCompounds;Se(Selenium)Compounds;SemimetalCompounds;SelenoAminoAcid;aminoacid;L-硒代蛋氨酸;原料;醫(yī)藥原料;醫(yī)用原料;食品添加;優(yōu)勢(shì)產(chǎn)品;飼料添加劑;其他;高純?cè)噭?非天然氨基酸;化學(xué)產(chǎn)品;合成材料中間體Mol文件3211-76-5.mol結(jié)構(gòu)式L-硒代蛋氨酸性質(zhì)熔點(diǎn)265°C比旋光度18o(c=1,1NHCl)沸點(diǎn)320.8±37.0°C(Predicted)折射率18°(C=0.5,2mol/LHCl)儲(chǔ)存條件-20°C溶解度H2O:50mg/mL酸度系數(shù)(pKa)2.26±0.10(Predicted)形態(tài)粉末顏色白色至類白色水溶解性solubleMerck14,8441InChIInChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1InChIKeyRJFAYQIBOAGBLC-BYPYZUCNSA-NSMILESC(O)(=O)[C@@H](N)CC[Se]CLogP0.152(est)CAS數(shù)據(jù)庫(kù)3211-76-5(CASDataBaseReference)L-硒代蛋氨酸用途與合成方法生物活性L-SelenoMethionine是Selenomethionine的L-異構(gòu)體，是硒的主要天然食物形式。L-SelenoMethionine是一種癌癥化學(xué)預(yù)防劑，可以通過(guò)飲食補(bǔ)充降低癌癥的發(fā)生率并誘導(dǎo)癌細(xì)胞凋亡。L-SelenoMethionine還可以增加谷胱甘肽過(guò)氧化物酶的表達(dá)。靶點(diǎn)HumanEndogenousMetabolite體外研究L-SelenoMethionine(1-500μM;24-72h)isselectivelyinhibitsthegrowthofprostatecancercells,comparedwithnormalcells.L-SelenoMethionine(500μM;48h)induceapoptosisinprostatecancercells.L-SelenoMethionine(500μM;48h)causesanChemicalbookincreaseinarrestintheG2-Mphaseofthecellcycleselectivelyinprostatecancercells.L-SelenoMethionine(5μM;24h)mitigatesgeneexpressionassociatedwiththecellularstressresponsefrom10cGyirradiation.CellViabilityAssayCellLine:Prostatecancercells(LNCaP,PC-3,andDU145)andnormalprostatecells(PrEC,PrSM,andPrSt)Concentration:1,5,10,50,100,500μMIncubationTime:24,48,72hoursResult:Inhibitedthegrowthofprostatecancercells,withalowerIC50(1-90μM)at72hthannormalprostatecells(>500μM).ApoptosisAnalysisCellLine:Prostatecancercells(LNCaP,PC-3,andDU145)andnormalprostatecells(PrEC,PrSM,andPrSt)Concentration:500μMIncubationTime:48hoursResult:ExhibitedthehighestlevelofDNAcondensationinandrogen-responsiveLNCaPcarcinomacells,followedbyPC-3andDU145cells.Exhibitedthenicked-endDNAlabelinginprostatecancercells.PromotedthePARPcleavageinprostatecancercells.CellCycleAnalysisCellLine:Prostatecancercells(LNCaP,PC-3,andDU145)andnormalprostatecells(PrEC,PrSM,andPrSt)Concentration:500μMIncubationTime:48hoursResult:Increasedthesub-G0-G1cellfractionofLNCaP(41.5%),PC-3(12.1%),andDU145cells(11.2%).CausedasignificantincreasesinG2cells,particularlyinLNCaP(13%),PC-3(32%),andDU145(20%)cells.RT-PCRCellLine:Humanthyroidepithelialcells(HTori-3)Concentration:5μMIncubationTime:24hoursResult:DownregulatedtheCDC6,GADD45A,FASandATF3inirradiatedcells.體內(nèi)研究L-SelenoMethionine(0.06-12μg/gdiet;p.o.for3d)partiallyorcompletelypreventthedecreaseintheserumorplasmalevelsoftotalantioxidantsinratsexposedtogammarays,protonsorHZEparticles.用途可以用于蛋白質(zhì)的結(jié)構(gòu)分析。拿此產(chǎn)品來(lái)飼養(yǎng)細(xì)菌，這樣最終形成的蛋白質(zhì)里的特定位置就會(huì)被硒所取代，便于結(jié)構(gòu)測(cè)定 |
| 結(jié)構(gòu)式： |
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金經(jīng)理 |
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