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雌馬酚 |
| CAS No.: |
94105-90-5 |
| 分子式： |
C15H14O3 |
| 分子量： |
242.27 |
| 備注： |
中文名稱雌馬酚中文同義詞納米脂質(zhì)體雌馬酚;R,S-雌馬酚;)-雌馬酚;(鹵)-EQUOL;(+)-雌馬酚;雌馬酚,(±)-雌馬酚;3-(4-羥基苯基)四氫苯并吡喃-7-醇;雌馬酚98%不是S型,混旋的英文名稱(+/-)-EQUOL英文同義詞7,4’-HoMoisoflavane;NV07α;3-(4-Hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-7-ol7-Hydroxy-3-(4-hydroxyphenyl)chroman4’,7-Isoflavandiol;3,4-Dihydro-3-(4-hydroxyphenyl)-2H-chromen-7-ol,(+/-)-Equol,4’,7-Isoflavandiol,7-Hydroxy-3-(4-hydroxyphenyl)chroman;4’,7-Isoflavandiol,(+/-)-Equol;4′,7-Dihydroxyisoflavane;(+/-)-Equol(GMP);(±)-EQUOL>=99.0%(TLC)CAS號(hào)94105-90-5分子式C15H14O3分子量242.27EINECS號(hào)618-999-2相關(guān)類別吡喃;醫(yī)藥原料;功能性食品添加;Metabolites;metabolite;Aromatics;Heterocycles;Intermediates&FineChemicals;Metabolites&Impurities;PharmaceuticalsMol文件94105-90-5.mol結(jié)構(gòu)式雌馬酚性質(zhì)熔點(diǎn)158-160?C沸點(diǎn)441.7±45.0°C(Predicted)密度1.286±0.06g/cm3(Predicted)儲(chǔ)存條件Inertatmosphere,Storeinfreezer,under-20°C溶解度溶于乙醇形態(tài)結(jié)晶粉末酸度系數(shù)(pKa)9.94±0.40(Predicted)顏色白色至淺黃色至淺紅色水溶解性SolubleinDMSOandmethanolor100%ethanol.Insolubleinwater.敏感性HygroscopicBRN87752InChIInChI=1S/C15H14O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-6,8,12,16-17H,7,9H2InChIKeyADFCQWZHKCXPAJ-UHFFFAOYSA-NSMILESC1OC2=CC(O)=CC=C2CC1C1=CC=C(O)C=C1雌馬酚用途與合成方法生物活性(±)-Equol是equol的外消旋體。Equol是大豆異黃酮黃豆苷和大豆黃素的代謝產(chǎn)物。體外研究EquolisfirstisolatedandidChemicalbookentifiedfrompregnant-mares’urineandlaterfoundintheurineofthegoat,cow,henandsheep.Equol,unlikethesoyisoflavonesdaidzeinorgenistein,hasachiralcenterandthereforecanoccuras2distinctdiastereoisomers.S-equolistheexclusiveproductofhumanintestinalbacterialsynthesisfromsoyisoflavonesandbothenantiomersarebioavailable.S-equolhasahighaffinityforestrogenreceptorbeta(Ki=0.73nM),whereasR-equolisrelativelyinactive.EquolcouldpromotetheproliferationanddifferentiationofratosteoblaststhroughactivatingtheER-PKCα-relatedsignalingpathway.Thealkalinephosphataseactivityalsoincreasessignificantlyinalloftheequoland17β-estradiol(E2)groups.Equolalsosignificantlyelevatestheosteocalcinlevels.體內(nèi)研究Equolisamodestnatriureticandvasorelaxantagentintherat.Orallyadministeredequolisabout8-foldlesspotentthanorallyadministeredfurosemide.Inisolatedaorticringsprecontractedbyadministrationofphenylephrine,administrationofequolrelaxesthecontractedaorta(concentrationforhalf-maximalactivity58.9±16μM).EquolpossessesanticanceractivitythatsuppressestumorformationviaapoptosisinductioninratswithDMBA-inducedmammaryglandtumors.Inaddition,equolshowsahepaticprotectiveeffectbyactingasanantioxidantandbyreducingapoptosis. |
| 結(jié)構(gòu)式： |
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聯(lián)系人： |
金經(jīng)理 |
地 址： |
湖北省武漢市東湖新技術(shù)開(kāi)發(fā)區(qū)光谷大道03號(hào) |
郵 編： |
430000 |
電 話： |
18995560451 |
手 機(jī)： |
15102708508 |
傳 真： |
18995560451 |
Q Q： |
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網(wǎng) 址： |
www.hbdhchem.com |
電子郵件： |
709783996@qq.com |
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